A generic toolkit for microfluidics and point-of-care diagnostics
What is Flowpad-Flowstretch?
FlowPad features disposable, credit card format microfluidic cartridges with fluidic channels designed to perform a selection of tests outside of a traditional lab environment. The integrated protocol can be complex by including all sample preparation steps—concentration, lysis, purification—as well as bio-analysis and detection procedures—qPCR, RPA, LAMP and ELISA.
An instrument leverages a chip carrier, a functional implementation system based on the microfluidic cartridge design. This instrument integrates a valve, a pump and a mixing chamber and is embedded into a toolkit. This toolkit delivers the diagnosis. It integrates actuators, a Peltier heater, magnetic actuators and on-board reagent recovery, as well as an optical sensing system, and associated software programs.
Both instrument and microfluidic cartridges are customdesigned based on clinical or manufacturing requirements.
Applications:
FlowPad finds applications in human medicine, agri-agro and environment industries:
Sample preparation at the sampling point —peptide, SiRNA isolation
Point-of-care testing and diagnostics —bacteria, viruses, biomarkers and proteins.
Companion diagnostic
- Cell encapsulation—spheroids, cells, etc.
Assessment of Chemical, Biological, Radiological and Nuclear (CBRN) risks
What's new?
CEA-Leti’s Flowpad-Flowstretch technology opens a new path to the future of testing:
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Tests in less than 2 hours: from raw biological sample to results
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Versatile, easy-to-use toolbox
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Compatible with multiple complex protocols—biological, chemical, etc.—and materials—silicon, glass, COC, polymers, etc.
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Reduces development and prototyping time
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Easily scalable for high-volume production at low-cost. CEA-Leti has perfected cartridge design and small-scale production.
- Full protocol integration
Flowpad-Flowstretch's Microfluidic cartridge:
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are user-friendly features plug-and-play fluidic connections with easy and efficient flow control
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operates with valves and a pump integrated into the cartridge
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are compatible with injection molding
What's next?
CEA-Leti is currently working in scaling to high-volume manufacturing both the
cartridge and the instrument with industrial partners.
New application: multiplex measurement card.